کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
342004 548579 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Disturbed social behavior and motivation in rats selectively bred for deficient sensorimotor gating
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Disturbed social behavior and motivation in rats selectively bred for deficient sensorimotor gating
چکیده انگلیسی

Deficient prepulse inhibition (PPI) of startle reflects disturbed sensorimotor gating found in certain neuropsychiatric disorders. We here tested whether rats selectively bred for deficient PPI are deteriorated in behavioral paradigms used to model negative symptoms of schizophrenia.Rats with low PPI preferred standard rat-chow when having the choice between lever-pressing for reward-pellets or freely available rat-chow, suggesting reduced motivation. Additionally, these rats show deteriorated social behavior during interaction with a juvenile rat.Rats selectively bred for low PPI may therefore be used as a model to study the biological mechanisms and therapeutic strategies of negative symptoms of schizophrenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 97, Issues 1–3, December 2007, Pages 250–253
نویسندگان
, , , , ,