کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3425812 1227300 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genomic characterization of novel dolphin papillomaviruses provides indications for recombination within the Papillomaviridae
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Genomic characterization of novel dolphin papillomaviruses provides indications for recombination within the Papillomaviridae
چکیده انگلیسی

Phylogenetic analysis of novel dolphin (Tursiops truncatus) papillomavirus sequences, TtPV1, -2, and -3, indicates that the early and late protein coding regions of their genomes differ in evolutionary history. Sliding window bootscan analysis showed a significant a change in phylogenetic clustering, in which the grouped sequences of TtPV1 and -3 move from a cluster with the Phocoena spinipinnis PsPV1 in the early region to a cluster with TtPV2 in the late region. This provides indications for a possible recombination event near the end of E2/beginning of L2. A second possible recombination site could be located near the end of L1, in the upstream regulatory region. Selection analysis by using maximum likelihood models of codon substitutions ruled out the possibility of intense selective pressure, acting asymmetrically on the viral genomes, as an alternative explanation for the observed difference in evolutionary history between the early and late genomic regions of these cetacean papillomaviruses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 378, Issue 1, 15 August 2008, Pages 151–161
نویسندگان
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