کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3428915 1228232 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Formation of membrane-defined compartments by tick-borne encephalitis virus contributes to the early delay in interferon signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Formation of membrane-defined compartments by tick-borne encephalitis virus contributes to the early delay in interferon signaling
چکیده انگلیسی

Interferons are key mediators of the innate antiviral response of the cell against viral infections. Viruses on the other hand have evolved various strategies to delay innate immunity in order to establish a productive infection. In this work we analyzed the pathway of interferon induction by the tick-borne encephalitis virus. We initially observed a consistent delay of interferon induction following virus replication. RIG-I, but not MDA5, and nuclear translocation of IRF3 were eventually required for interferon activation pointing to a defect in pattern recognition receptor's signaling. However, viral proteins could not directly inhibit the pathway suggesting an indirect mechanism. We found that dsRNA replication intermediates and replicated viral RNA localized to membrane-defined perinuclear compartments that resisted RNAse treatment. Thus, initial escape from innate immunity involved the formation of replication vesicles that may function as a barrier to pattern recognition receptors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 163, Issue 2, February 2012, Pages 660–666
نویسندگان
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