کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3430423 | 1594398 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serotype-specificity of recombinant fusion proteins containing domain III of dengue virus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Serotype-specificity of recombinant fusion proteins containing domain III of dengue virus Serotype-specificity of recombinant fusion proteins containing domain III of dengue virus](/preview/png/3430423.png)
چکیده انگلیسی
Here, the antigenic specificity of the recombinant fusion proteins containing aa 286–426 of the dengue envelope protein fused to P64k from Neisseria meningitidis and the cross-reactive antibody response induced in immunized mice and monkeys were evaluated. The anti-dengue mice antibodies showed a higher reactivity to the homologous recombinant proteins compared to the wide cross-reactivity observed by dot blot to the viral antigens. The immune response induced by the recombinant proteins in mice and monkeys, was highly serotype specific. The serotype-specificity associated with these recombinant proteins in addition to the high antigenicity, immunogenicity and protecting capacity suggest their advantages as possible vaccine candidates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 138, Issues 1–2, December 2008, Pages 135–138
Journal: Virus Research - Volume 138, Issues 1–2, December 2008, Pages 135–138
نویسندگان
Alienys Izquierdo, Lidice Bernardo, Jorge Martin, Emidalys Santana, Lisset Hermida, Gerardo Guillén, María G. Guzmán,