Efficacy of scaling and root planing with and without adjunct antimicrobial photodynamic therapy on the expression of cytokines in the gingival crevicular fluid of patients with periodontitis: A systematic review

• Six clinical trials were included in the present systematic review.
• Two studies reported lower pro-inflammatory (IL-1β, TGF-β1 and MMP-8) cytokines among individuals that underwent SRP with adjunct aPDT compared with SRP alone.
• Three studies reported reduction in selective cytokines in the GCF following SRP with adjunct aPDT compared with SRP alone.
• In one study SRP with adjunct aPDT failed to reduce GCF IL-1β at follow-up.

BackgroundThe aim of the present review was to study the efficacy of scaling and root planing (SRP) with and without adjunct antibacterial photodynamic therapy (aPDT) on the expression of cytokines in the gingival crevicular fluid (GCF) of patients with periodontitis.MethodsIn order to address the focused question: “What is the efficacy of SRP with and without aPDT on the expression of cytokines in the GCF of patients with periodontitis” an electronic search without time or language restrictions was conducted up to and including July 2016 in indexed databases using various key words. The exclusion criteria included reviews, laboratory and experimental studies, case reports, commentaries, letters to the editor, interviews, updates, studies where intervention group received aPDT without previous SRP, and studies where local delivery of antibiotics was used as adjunctive therapy to aPDT.ResultsSix randomized control trials were included in the present systematic review. All studies included a control group which received only SRP. Results from 34% of studies reported lower cytokine levels among individuals receiving adjunct aPDT to SPT compared to patients receiving SRP alone. Selective cytokines reduction in the GCF following SRP with adjunct aPDT compared with SRP alone was reported in 50% of the studies. In one study SRP with adjunct aPDT failed to reduce GCF cytokine concentration.ConclusionFrom the literature reviewed the efficacy aPDT as adjunct to SRP in downregulating GCF cytokines remains debatable. Further well-designed studies are needed in this regard.