کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3841315 1247972 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Myeloid cells functioning in tumor vascularization as a novel therapeutic target
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Myeloid cells functioning in tumor vascularization as a novel therapeutic target
چکیده انگلیسی

Angiogenesis, the sprouting of new blood vessels to sustain growth, is an important new target in solid tumor therapy. Initial studies focused on the role of the tumor cell in promoting angiogenesis; yet more recent work has demonstrated that host cells in the tumor microenvironment also play a critical role in tumor vascularization. Additionally, vasculogenesis in which new blood vessels develop from vascular progenitor cells also contributes to tumor growth. Recent studies propose a central role for cells of the myeloid lineage in triggering vessel growth by releasing angiogenic factors and perhaps by incorporating directly into nascent blood vessels. We will review studies that support a critical role for myeloid cells in neovascularization, with a focus on cells that express various monocytic/dendritic cell markers, including vascular leukocytes (VLCs), Tie2+ monocytes, and vascular endothelial growth factor receptor 2 (VEGFR2)+ monocytes, among others. The evidence that these myeloid cells represent bona fide therapeutic targets for solid tumors will be reviewed. Finally, we will address some controversies and challenges in the field with a focus on future directions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 151, Issue 2, February 2008, Pages 59–67
نویسندگان
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