کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3980608 | 1257442 | 2008 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Apoptosis and non-apoptotic deaths in cancer development and treatment response Apoptosis and non-apoptotic deaths in cancer development and treatment response](/preview/png/3980608.png)
SummaryResistance to apoptosis is closely linked to tumorigenesis, as it enables malignant cells to expand even in a stressful environment. Cells resistant to apoptosis are also assumed to be resistant to anti-cancer therapies. Apoptosis has therefore taken a central position in cell death research. However, its contribution to treatment success is highly debated for solid tumors. It becomes more and more clear that cells can also die by non-apoptotic mechanisms, such as autophagy, mitotic catastrophe and necrosis. In this review, we summarize the current knowledge regarding the molecular pathways that underlie these apoptotic and non-apoptotic death pathways, and discuss the clinical data that have now accumulated to evaluate their roles in tumor development and cancer treatment.
Journal: Cancer Treatment Reviews - Volume 34, Issue 8, December 2008, Pages 737–749