کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3987103 | 1601433 | 2010 | 8 صفحه PDF | دانلود رایگان |

BackgroundStaging laparoscopy (SL) may prevent non-therapeutic laparotomy in patients with otherwise resectable pancreatico-biliary cancers, but evidence is inconclusive. This meta-analysis aims to ascertain the true benefit of SL.MethodsAll studies undertaking SL as a diagnostic sieve were included and data homogenised. Standard meta-analytical tools with emphasis on sensitivity testing and meta-regression to detect the cause for heterogeneity between studies were used.Results29 studies satisfied the criteria. 3305 patients underwent SL of which 12 were incomplete. Morbidity (n = 15) and mortality (n = 1) was low. True yield of SL for pancreatic/perpancreatic cancers (PPC) was 25% (95% CI 24–27) with a Diagnostic Odds Ratio (DOR) of 104 (95% CI 48–227). Resection rate improved from 61% to 80%. For proximal biliary cancers (PBC), SL increased the curative resection rate from 27% to 50%, with true yield of 47% (95% CI 42–52) and a DOR 61 (95% CI 19–189). Sub-group analysis for detection of liver and peritoneal lesions demonstrated a sensitivity of 88% (95% CI 83–92) and 92% (95% CI 84–96) for PPC; 83% (95% CI 69–92) and 93% (95% CI 81–99) for PBC, respectively. There was no between-study heterogeneity for peritoneal lesions. However for detection of local invasion, sensitivity was low: 58% (95% CI 51–65) for PPC and only 34% (95% CI 22–47) for PBC. Meta-regression did not reveal any cause for the observed heterogeneity between studies.ConclusionSL offers significant benefit to patients with resectable pancreatico-biliary cancers in avoiding non-therapeutic laparotomy and should be adopted in routine clinical practice in a judicious algorithm.
Journal: European Journal of Surgical Oncology (EJSO) - Volume 36, Issue 10, October 2010, Pages 941–948