کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3987758 1601454 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A critical analysis of treatment strategies in desmoid tumours: a review of a series of 106 cases
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
A critical analysis of treatment strategies in desmoid tumours: a review of a series of 106 cases
چکیده انگلیسی

BackgroundThe management of desmoid tumours, previously based on strategies employed for sarcomas, should be reassessed, given the morbidity of interventions used in their treatment.MethodsLong-term follow-up (median 123 months) of a series of 106 treated patients with 69 primary and 37 recurrent desmoids, in order to study natural history and outcome.ResultsDesmoids typically evolved actively over a median period of 3 years, and stabilised thereafter. Recurrences or progression most commonly occurred between 14 and 17 months. Risk factors for recurrence were presentation (primary vs. recurrent), gender, tumour location and resection margins. However, survival was independent from these factors, with equivalent survival whether resection had been performed or not. Tumour control and functional outcome depended on location and presentation. Functional impairment was proportional to number of operations and whether patients had received radiotherapy. Recurrences were observed in 12/23 patients after radiotherapy.ConclusionDesmoids are relatively indolent tumours needing different approaches than sarcomas. Direct surgery is advisable only in primary lower trunk wall/girdle locations. Wait-and-see and medical treatment is preferable in other types of presentations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 35, Issue 2, February 2009, Pages 129–134
نویسندگان
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