کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3997668 1259166 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IN-VITRO evidence for the protective properties of the main components of the Mediterranean diet against colorectal cancer: A systematic review
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
IN-VITRO evidence for the protective properties of the main components of the Mediterranean diet against colorectal cancer: A systematic review
چکیده انگلیسی


• The Mediterranean Diet (MD) could protect from colorectal cancer.
• Polyphenols, lycopene, resveratrol, capsaicin have in vitro anticancer properties.
• Supplemented components does not lead to the same results as the complete MD.
• In-vitro studies will hopefully improve our understanding.

AimEpidemiological studies have shown that the incidence and mortality rates of colorectal cancer (CRC) vary over 10-fold worldwide where within Westernized societies lower rates are observed amongst populations living within the Mediterranean basin, suggesting a significant influence of environment and dietary style in CRC carcinogenesis. Interpretation of the data concerning the benefits of mediterranean (MD) diet is difficult in vivo because of the variability of alimentary regimens used, the differing compliance with dietary supplementation and because of the non-uniform duration of patient cohort observation. Therefore, the aim of this review is to evaluate the in-vitro effects on colorectal cancer cell lines.Methodsthe literature concerning the in-vitro effects of 4 of the principal components symbolizing the MD such as olive oil (polyphenol), red chili (capsaicin), tomato (lycopene) and red grapes (resveratrol) have been systematically reviewed.ResultsSeveral studies have demonstrated that polyphenols form olive oil, lycopene, resveratrol and capsaicin have multiple anticancer properties affecting several metabolic pathways involved in cancerogenesis, apoptosis, and metastasis in CRC cell lines.ConclusionThis review summarizes some of the most recent data potentially supportive of the use of MD in CRC chemoprevention, analyzing the in vitro effects of individual components of the MD on CRC cell development, progression, metastasis and apoptosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgical Oncology - Volume 24, Issue 3, September 2015, Pages 145–152
نویسندگان
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