کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4178996 1276526 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced Thickness of Medial Orbitofrontal Cortex in Smokers
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Reduced Thickness of Medial Orbitofrontal Cortex in Smokers
چکیده انگلیسی

BackgroundStructural deficiencies within the prefrontal cortex might be related to drug-taking behavior that prevails in smokers. Cortical thickness has been found to be a structural modulator of cerebral function and cognition and a subtle correlate of mental disorders. However, to date an analysis of cortical thickness in smokers compared with never-smokers has not been undertaken.MethodsWe acquired high-resolution magnetic resonance imaging scans from 22 smokers and 21 never-smokers and used FreeSurfer to model the gray-white and pial surfaces for each individual cortex to compute the distance between these surfaces to obtain a measure of cortical thickness. The main cortical folds were aligned across individuals with FreeSurfer's surface-based averaging technique to compare whole brain differences in cortical thickness between smokers and never-smokers.ResultsRelative to never-smokers, smokers showed greater cortical thinning in the left medial orbitofrontal cortex (mOFC). Cortical thickness measures extracted from mOFC correlated negatively with the amount of cigarettes consumed/day and the magnitude of lifetime exposure to tobacco smoke.ConclusionsThe brains of smokers are structurally different from those of never-smokers in a dose-dependent manner. The cortical thinning in mOFC in smokers relative to never-smokers might imply dysfunctions of the brain's reward, impulse control, and decision-making circuits. Related behavioral correlates are suggested to be relevant for smoking initiation and maintenance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 68, Issue 11, 1 December 2010, Pages 1061–1065
نویسندگان
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