کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4179752 1276565 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Smoking Cessation and Variations in Nicotinic Acetylcholine Receptor Subunits α-5, α-3, and β-4 Genes
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Smoking Cessation and Variations in Nicotinic Acetylcholine Receptor Subunits α-5, α-3, and β-4 Genes
چکیده انگلیسی

BackgroundEvidence has recently accumulated that single nucleotide polymorphisms in the genetic region encoding the nicotinic acetylcholine receptor subunits α-5, α-3, and β-4 are associated with smoking and nicotine dependence. We aimed to determine whether these genetic variations are also predictive of smoking cessation.MethodsLifetime history of smoking was assessed by questionnaire at enrolment into a large epidemiological study of the German elderly population (ESTHER study). Cox proportional hazards modeling was applied in a retrospective cohort approach to determine the associations of individual polymorphisms and haplotypes with smoking cessation probability in 1446 subjects who reported regularly smoking more than 20 cigarettes at some point in their lives.ResultsGiven the genotype distributions and number of cessation events observed, the power to detect associations ranged from 54% to 97% for hazard ratios of 1.2 to 1.4 in case of the variant with strongest prior evidence (α = .05). Nonetheless, neither individual polymorphisms nor inferred multilocus haplotypes were significantly associated with smoking cessation.ConclusionsAlthough the robust association of the nicotinic acetylcholine receptor subunit genes investigated with smoking-related phenotypes is an apparent success story of genetic epidemiology, the respective variations seem to exert no relevant influence on smoking cessation probability in heavy smokers in the general population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 65, Issue 8, 15 April 2009, Pages 691–695
نویسندگان
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