کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4179782 | 1276566 | 2007 | 4 صفحه PDF | دانلود رایگان |
BackgroundExcessive glutamatergic neurotransmission may contribute to the pathophysiology of major depressive disorder (MDD). Recent evidence suggests that riluzole and other agents that target glutamate neurotransmission may show antidepressant activity.MethodsTen patients with treatment-resistant depression had riluzole added to their ongoing medication regimen for 6 weeks, followed by an optional 6-week continuation phase. Depression and anxiety severity were assessed using the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS). Linear mixed models were used to test for a linear trend in HDRS and HARS scores across time with treatment.ResultsSubjects’ HDRS and HARS scores declined significantly following the initiation of riluzole augmentation therapy. The effect of riluzole was significant at the end of the first week of treatment and persisted for the 12-week duration of the study.ConclusionsThese data suggest that riluzole augmentation produces antidepressant and anxiolytic effects in patients with treatment-resistant depression.
Journal: Biological Psychiatry - Volume 61, Issue 6, 15 March 2007, Pages 822–825