کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4180488 1276606 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Erythropoietin Reduces Neural and Cognitive Processing of Fear in Human Models of Antidepressant Drug Action
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Erythropoietin Reduces Neural and Cognitive Processing of Fear in Human Models of Antidepressant Drug Action
چکیده انگلیسی

BackgroundErythropoietin (Epo) has neuroprotective and neurotrophic effects in animal models and affects cognitive and associated neural responses in humans. These effects have highlighted Epo as a candidate for treatment of psychiatric disease including schizophrenia and depression. The current study aimed to explore the effects of Epo on neural and behavioral measures of emotional processing relevant for depression and the effects of conventional antidepressant medication.MethodsIn the present study, we used functional magnetic resonance imaging to explore the effects of Epo (40,000 IU) versus saline on the neural processing of happy and fearful faces in 23 healthy volunteers. Facial expression recognition was assessed outside the scanner.ResultsOne week after administration, Epo reduced neural response to fearful versus neutral faces in the occipito-parietal cortex consistent with reduced attention to fear. Erythropoietin additionally reduced recognition of fearful facial expressions without affecting recognition of other emotional expressions. These actions occurred in the absence of changes in hematological parameters.ConclusionsThe present study demonstrates that Epo directly modulates brain responses to emotional information in humans in a manner consistent with the actions of conventional antidepressants. The characterization of the effects of Epo in a clinically depressed group is therefore warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 62, Issue 11, 1 December 2007, Pages 1244–1250
نویسندگان
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