کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4180785 1276619 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exaggerated Affect-Modulated Startle During Unpleasant Stimuli in Borderline Personality Disorder
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Exaggerated Affect-Modulated Startle During Unpleasant Stimuli in Borderline Personality Disorder
چکیده انگلیسی

BackgroundExcessive emotional responding is considered to be a hallmark of borderline personality disorder (BPD). The affect-modulated startle response is a reliable indicator of emotional processing of stimuli. The aim of this study was to examine emotional processing in BPD patients (n = 27) and healthy control subjects (n = 21).MethodsParticipants viewed an intermixed series of unpleasant, borderline-salient (e.g., “hate”), and neutral (e.g., “view”) words and were instructed to think about the meaning of the word for them personally while eyeblink responses were assessed.ResultsThe BPD patients exhibited larger startle eyeblink during unpleasant but not neutral words, indicating exaggerated physiological affect. This finding remained significant when we controlled for comorbid diagnoses, including generalized anxiety disorder and post-traumatic stress disorder. Greater symptom severity was associated with greater affective-startle difference scores (unpleasant-neutral).ConclusionsConsistent with the symptom of affective dysregulation, these results suggest an abnormality in the processing of unpleasant emotional stimuli by BPD patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 62, Issue 3, 1 August 2007, Pages 250–255
نویسندگان
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