کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4180957 1276626 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does the Child Behavior Checklist Juvenile Bipolar Disorder Phenotype Identify Bipolar Disorder?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Does the Child Behavior Checklist Juvenile Bipolar Disorder Phenotype Identify Bipolar Disorder?
چکیده انگلیسی

BackgroundA profile of Child Behavior Checklist(CBCL) T-scores ≥70 on the attention problems, aggression, and anxious/depressed subscales has been proposed to identify juvenile bipolar disorder(JBD). We tested this hypothesis in a population-based sample.MethodsData for this analysis come from a birth-records-based twin sample having semi-structured interview and CBCL data (N = 1,346). We compared prevalence of DSM-IV psychiatric disorders and suicidal behaviors in CBCL-JBD and non-CBCL-JBD subjects. Twin modeling assessed genetic and environmental contributions to CBCL-JBD. Associations with DRD4 and DAT1 were examined using chi-square tests.ResultsThe prevalence of CBCL-JBD was 2.5%. No subjects with CBCL-JBD met criteria for bipolar or other mood disorders. CBCL-JBD subjects had more oppositional defiant disorder (ODD), conduct disorder(CD), and attention deficit hyperactivity disorder(ADHD). The CBCL-JBD profile was uncommon in these disorders. CBCL-JBD subjects more frequently endorsed suicidal behaviors. The CBCL-JBD profile was heritable and associated with the number of DAT1 9-repeat 3’ untranslated region alleles.ConclusionsThe CBCL-JBD phenotype does not correspond with a semi-structured interview assessment of JBD. ADHD, CD, and ODD are common in children with CBCL-JBD but do not account for the profile. Increased suicidal behaviors indicate substantial impairment in CBCL-JBD subjects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 62, Issue 2, 15 July 2007, Pages 115–120
نویسندگان
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