کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4181018 1276630 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
White-Matter Integrity Predicts Stroop Performance in Patients with Geriatric Depression
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
White-Matter Integrity Predicts Stroop Performance in Patients with Geriatric Depression
چکیده انگلیسی

BackgroundThis study tested the hypothesis that microstructural white matter abnormalities in frontostriatal-limbic tracts are associated with poor response inhibition on the Stroop task in depressed elders.MethodFifty-one elders with major depression participated in a 12-week escitalopram trial. Diffusion tensor imaging was used to determine fractional anisotropy (FA) in white matter regions. Executive function (response inhibition) was assessed with the Stroop task. Voxelwise correlational analysis was used to examine the relationship between Stroop performance and fractional anisotropy.ResultsSignificant associations between FA and Stroop color word interference were evident in multiple frontostriatal-limbic regions, including white matter lateral to the anterior and posterior cingulate cortex and white matter in prefrontal, insular, and parahippocampal regions.ConclusionsThese findings suggest that microstructural white matter abnormalities of frontostriatal-limbic networks are associated with executive dysfunction of late-life depression. This observation provides the rationale for examination of specific frontostriatal-limbic pathways in the pathophysiology of geriatric depression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 61, Issue 8, 15 April 2007, Pages 1007–1010
نویسندگان
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