کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4181170 1276640 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prenatal, Perinatal, and Postnatal Risk Factors in Obsessive–Compulsive Disorder
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Prenatal, Perinatal, and Postnatal Risk Factors in Obsessive–Compulsive Disorder
چکیده انگلیسی

BackgroundThe etiology of obsessive–compulsive disorder (OCD) remains unknown, although it is thought to involve an interaction of genetic and environmental factors. This study aimed to identify prenatal, perinatal, and postnatal risk factors in OCD.MethodsWe compared retrospectively 68 OCD patients to 70 control subjects based on responses given on a standardized questionnaire. The questionnaire was designed to evaluate environmental factors, with a special focus on gestation, labor, birth, and early infancy aspects.ResultsThe group of OCD patients had risk factors with greater frequency than the control group. Notable among the significant findings (p ≤ 0.001) were edema of the hands, feet, or face and excessive weight gain during gestation; hyperemesis gravidarum; prolonged labor; preterm birth; and jaundice. When socioeconomic class was used as a covariable in the logistic regression analysis, prolonged labor and edema during pregnancy remained statistically significant.ConclusionsSome early risk factors may be associated with the expression of OCD later in life such as edema during pregnancy and prolonged labor. If our findings are confirmed in future studies, greater attention should be given to such factors in predisposed individuals, especially in prenatal care and delivery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 61, Issue 3, 1 February 2007, Pages 301–307
نویسندگان
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