کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4184715 1277324 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between cingulum bundle structure and cognitive performance: An observational study in major depression
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Association between cingulum bundle structure and cognitive performance: An observational study in major depression
چکیده انگلیسی

BackgroundMajor depression can be regarded as a systemic neurobehavioral disorder resulting from dysfunction of the limbic-cortical networks. The cingulum bundle represents a major association fiber tract of those networks. The aim of our study was to determine the association of brain structural tissue markers of the cingulum bundle and cognitive function in patients with major depression.MethodsRegion-of-interest-based analyses of the middle-anterior and middle-posterior cingulum bundle fractional anisotropy (FA) and mean diffusivity (MD) using color-coded diffusion-tensor imaging and neuropsychological assessment in 14 patients with major depression.ResultsFA of the middle-anterior and middle-posterior cingulum bundle was significantly correlated to the performance in a planning and divided attention task. Furthermore, MD of the middle-posterior cingulum bundle was significantly correlated to a planning task. There was no significant correlation between FA and MD of the cingulum bundle and selective attention or memory.ConclusionsBrain structural tissue markers of the middle-anterior and middle-posterior cingulum bundle were found to be associated with executive functioning and divided attention in patients with major depression. Disconnection within the limbic-cortical networks may underlay cognitive dysfunction in major depression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Psychiatry - Volume 25, Issue 6, October 2010, Pages 355–360
نویسندگان
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