کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4184877 1277330 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder
چکیده انگلیسی

The basal ganglia represents a key component of the pathophysiological model for obsessive-compulsive disorder (OCD). This brain region is part of several neural circuits, including the orbitofronto-striatal circuit and dorsolateral prefronto-striatal circuit. There are, however, no published studies investigating those circuits at a network level in non-medicated patients with OCD. Resting state functional magnetic resonance imaging scans were obtained from 20 non-medicated patients with OCD and 23 matched healthy volunteers. Voxelwise statistical parametric maps testing strength of functional connectivity of three striatal seed regions of interest (ROIs) with remaining brain regions were calculated and compared between groups. We performed additional correlation analyses between strength of connectivity and the severity scores for obsessive-compulsive symptoms, depression, and anxiety in the OCD group. Positive functional connectivity with the ventral striatum was significantly increased (Pcorrected <.05) in the orbitofrontal cortex, ventral medial prefrontal cortex and dorsal lateral prefrontal cortex of subjects with OCD. There was no significant correlation between measures of symptom severity and the strength of connectivity (Puncorrected <.001). This is the first study to investigate the corticostriatal connectivity in non-medicated patients with OCD. These findings provide the first direct evidence supporting a pathophysiological model involving basal ganglia circuitry in OCD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Psychiatry - Volume 26, Issue 7, October 2011, Pages 463–469
نویسندگان
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