Among multiple sclerosis and fatigue

BackgroundFatigue is commonly reported in patients with multiple sclerosis (MS), however, its relations to patient’s social and clinical characteristics are still investigated insufficiently.ObjectiveTo explore the peculiarities of association between social and clinical characteristics and fatigue in patients with relapsing-remitting multiple sclerosis (RRMS).MethodsThe study enrolled randomly selected volunteered RRMS patients. All of them were asked to complete or undergo the following: standard socio-demographic questionnaire, Fatigue Severity Scale (FSS), Medical Outcomes Study Sleep scale (MOSS), Numerical Rating Scale (NRS) for pain, Hospital Anxiety and Depression Scale (HADS) and the thirty-six item Short Form Health Survey (SF-36). Multiple linear regression model was used to assess the relationship between fatigue and socio-demographic and clinical characteristics of participants.ResultsThe mean FSS score value was 5.3 ± 3.1. The total 68.6% of patients reported the prevalence of fatigue and 21.9% and 19.7% suffered from depression and anxiety respectively. Mean value of Physical and Mental component of health related quality of life (HRQOL) constituted 40.4 and 44.5 points accordingly. The study revealed the association between fatigue and higher disability, depression and lower physical component of HRQOL.ConclusionRRMS patients with higher physical disability and depression score, and lower physical QOL suffered from fatigue more frequently than the ones with lower physical disability and depression score and higher physical QOL.