کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4188354 1608285 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcranial direct current stimulation of prefrontal cortex: An auditory event-related potential and proton magnetic resonance spectroscopy study
ترجمه فارسی عنوان
تحریک جریان مستقیم ترانس کرانانی قشر پیشانی: یک پتانسیل مربوط به رویداد شنوایی و مطالعه اسپکتروسکوپی رزونانس مغناطیسی پروتون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

Transcranial direct current stimulation (tDCS) is a non-invasive intervention altering neural plasticity by modulating neuronal excitability of pre- and postsynaptic neuron populations, which has been shown to improve depression symptoms and cognition. We investigated the effects of a single session of 20 min of 2 mA left-prefrontal anodal versus sham stimulation on auditory event-related potentials (ERPs) in 11 male and 5 female healthy subjects (mean age of 28.6 [SD 6.2] years) by employing a randomized single-blind crossover design. Stimulation effects on cortical glutamate (Glu) and glutamine (Glx) levels were subsequently measured in 12 of the 16 healthy subjects in a 3 T proton magnetic resonance spectroscopy scan. tDCS was associated with a significant increase of N1 amplitudes while smaller P3b amplitudes correlated with higher cortical Glu and Glx levels in the stimulated brain area when performing an auditory go/no-go discrimination task. tDCS did not change mismatch negativity, nor task performance or cortical Glu/Glx levels which, together with N1 amplitudes, depended on stimulation order (“sham” versus “active”). Increased N1 amplitudes are consistent with higher levels of cortical excitability following prefrontal anodal tDCS. The failure to replicate Glu/Glx changes with tDCS may have been masked by between-session carry-over effects while ceiling effects may have masked tDCS effects on task performance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurology, Psychiatry and Brain Research - Volume 20, Issue 4, December 2014, Pages 96–101
نویسندگان
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