کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4188552 | 1278000 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dominios cognitivos en la depresión unipolar. TeorÃas multimodales y nuevas perspectivas terapéuticas
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Major depressive disorder (MDD) is considered the prototype of pathology heterogeneous group of Depressive Disorders (DSM-5). The MDD is a pleomorphic pathology and multisystem polygenic disorder emerging from different levels of interacting genes and environmental factors. Unfortunately, the increasing cost of depression and related affective disorders has not been paralleled by improvements in the efficacy of antidepressant treatment. Current challenges are focused on finding therapeutic targets capable of modulating different pathophysiological levels from the genome (eg. histone deacetylase inhibitors), and systemic metabolic variables (eg. drugs that interact at the level of oxidative and inflammatory phenomena), to higher order cognitive mechanisms (eg. executive functions). This brief review aims to analyze the neuropsychological terms we considered necessary in the clinical assessment of patients with MDD and the pathophysiological mechanisms and new therapeutic seeking to overcome current limitations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PsiquiatrÃa Biológica - Volume 22, Issue 2, MayâAugust 2015, Pages 33-38
Journal: PsiquiatrÃa Biológica - Volume 22, Issue 2, MayâAugust 2015, Pages 33-38
نویسندگان
Cristóbal Gastó, Joana Guarch, VÃctor Navarro,