Desvenlafaxina, un nuevo IRSN para el tratamiento de la depresión mayor: Revisión de la literatura

Desvenlafaxine (DESV) is a new antidepressant within the group of serotonin-norepinephrine reuptake inhibitors (SNRI). Various controlled clinical trials have demonstrated its efficacy in the treatment of adult patients with a major depressive disorder. These studies have evaluated the efficacy of DESV in doses that varied between 50 mg and 400 mg/day. However, the therapeutic dose of DESV has been established at 50 mg/ day, with no additional therapeutic benefits being observed at higher doses. The tolerability and safety profile of DESV at this dose is very favourable, a fact that is associated with a minimal impact on the cytochrome P450 system which gives it the additional advantage of a lower risk of pharmacokinetic interactions. This review provides a summary of the pharmacological data of DESV, as well as the pre-clinical and clinical results on its efficacy and safety.