El sistema noradrenérgico en la neurobiología de la depresión

Study of neurotransmission targets for antidepressants seems to be the most effective approach for the design of new antidepressant drugs. In this context, the α2-adrenoceptors play a major role in the mechanism of action of these agents. In addition, antidepressants, whether with a noradrenergic or a serotonergic profile, are able to modulate the noradrenergic system, demonstrating that both systems are modulated at the same time in the central nervous system.