Efectos de la administración de (RS)-2-cloro-5-hidroxifenilglicina (CHPG) sobre la conducta agonística en ratones

Several studies have indicated that ionotropic glutamate receptors (especially NMDA and AMPA) are involved in the modulation of aggressive behavior in animal models. In contrast, the role of metabotropic glutamate receptors (mGlu) is less well known. mGlu5 receptors are found in high concentrations in the limbic brain structures implicated in emotional behaviors, including aggression. This study examines the effects of CHPG (0.75, 1.5, 3, 6 and 12 mg/kg, ip), a selective mGlu5 receptor agonist, on agonistic behavior elicited by isolation in male mice. Individually housed mice were exposed to an anosmic opponent in a neutral area 30 min after drug administration. In addition to other behaviors, aggressive (threat and attack) and exploratory behaviors were evaluated for 10 min using an ethologically based analysis. The results indicate that CHPG administration produced no significant effects on agonistic behavior at any of the doses used. These findings could be related to several factors such as the specific characteristics of the ligand used (partial vs total agonist), the chosen dose range, or the interval between drug administration and the evaluation of its effects.