کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4188857 | 1278035 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aumento de los valores de las proteÃnas neurregulina 1 y ErbB4 en la corteza prefrontal de pacientes esquizofrénicos
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
روانپزشکی و بهداشت روانی
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![عکس صفحه اول مقاله: Aumento de los valores de las proteÃnas neurregulina 1 y ErbB4 en la corteza prefrontal de pacientes esquizofrénicos Aumento de los valores de las proteÃnas neurregulina 1 y ErbB4 en la corteza prefrontal de pacientes esquizofrénicos](/preview/png/4188857.png)
چکیده انگلیسی
Neuregulin-1 (NRG1) and its receptor, ErbB4, have been implicated in schizophrenia at both gene and transcript levels. The present investigation compared NRG1 and ErbB4 protein levels in prefrontal cortical (PFC) cytoplasmic and nuclear fractions among normal, schizophrenic, bipolar and major depressed subjects from the Stanley Consortium. We used immunoblotting procedures to examine potential NRG1 and ErbB4 immunoreactive bands, but specifically quantified NRG1 immunoreactive signals at 42, 48 and 53Â kDa and ErbB4 immunoreactive signals at 21, 55, 60 and 180Â kDa. PFC cytoplasmic 53Â kDa NRG1 protein levels were significantly increased (â¼20%) in schizophrenic patients relative to each of the other subject groups. We also detected diagnostic effects on PFC cytoplasmic full-length (180Â kDa) ErbB4 protein levels, and post hoc tests revealed that these quantities were significantly increased (â¼30%) in schizophrenic patients relative to normal and to depressed subjects. In addition, we examined the levels of potential ErbB4 cleavage products at 21, 55 and 60Â kDa relative to those of full-length ErbB4 in the PFC fractions. We detected trends for diagnostic effects on PFC cytoplasmic 21Â kDa/180Â kDa and 55Â kDa/180Â kDa ratios, and post hoc tests revealed that these ratios were significantly reduced in schizophrenic patients relative to normal individuals. Our investigation suggests that schizophrenia-associated NRG1 and ErbB4 mRNA elevations also occur at the protein level and may be specific to schizophrenia. We hypothesize that ErbB4 proteolytic processing may also be altered in schizophrenia, yielding altered ratios of functionally distinct forms of ErbB4. Published by Elsevier B.V.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PsiquiatrÃa Biológica - Volume 17, Issue 2, AprilâJune 2010, Pages 54-62
Journal: PsiquiatrÃa Biológica - Volume 17, Issue 2, AprilâJune 2010, Pages 54-62
نویسندگان
Victor Z. Chong, Mia Thompson, Senda Beltaifa, Maree J. Webster, Amanda J. Law, Cynthia Shannon Weickert,