کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4226468 1609792 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of semi-quantitative dynamic contrast-enhanced MRI parameters for prostate cancer in correlation to whole-mount histopathology
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی رادیولوژی و تصویربرداری
پیش نمایش صفحه اول مقاله
Evaluation of semi-quantitative dynamic contrast-enhanced MRI parameters for prostate cancer in correlation to whole-mount histopathology
چکیده انگلیسی

PurposeTo evaluate the use of semi-quantitative dynamic contrast-enhanced MRI (DCE-MRI) parameters for the detection of prostatic carcinoma in correlation to whole-mount histopathology.Materials and methodsFifty-three patients with biopsy-proven prostate cancer were examined by DCE-MRI at 1.5-T. Cancerous and benign prostatic tissue regions of interest were delineated based on the histopathology of whole-mount sections and several semi-quantitative parameters were calculated: time to peak (TTP), maximal contrast enhancement (Cpeak), speed of contrast uptake (Wash-in) and clearance rate of the contrast agent (Wash-out). The area under the ROC curve was determined for each parameter.ResultsWithin individual patients, a consistently higher Cpeak and faster Wash-in were present in cancerous compared to benign prostatic tissue. Both the TTP and the Wash-out occurred more rapidly in tumour tissue than in normal prostatic tissue. Despite a considerable inter-patient overlap of parameter values between tumour and normal prostatic tissue, area under the ROC curve analysis demonstrated that the Wash-in was a good discriminator for cancer and benign tissue (AUC 0.82). Combination of the Wash-in and the Wash-out proved to be even more accurate (AUC 0.87) to discriminate between cancerous and benign prostatic regions.ConclusionThe Wash-in is a useful parameter for prostate cancer detection by DCE-MRI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Radiology - Volume 81, Issue 3, March 2012, Pages e217–e222
نویسندگان
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