کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4227487 1609814 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Focal nodular hyperplasia of the liver in longterm survivors of neuroblastoma: How much diagnostic imaging is necessary?
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی رادیولوژی و تصویربرداری
پیش نمایش صفحه اول مقاله
Focal nodular hyperplasia of the liver in longterm survivors of neuroblastoma: How much diagnostic imaging is necessary?
چکیده انگلیسی

ObjectivesFocal nodular hyperplasia of the liver is a tumor-like lesion, uncommon in children, but it has recently been more frequently observed in children treated for malignant diseases, especially neuroblastoma. The aetiology is unclear, the pathogenesis remains controversial. Focal nodular hyperplasia of the liver is suspected to be a sequela of tumor therapy.MethodsBesides the clinical data we evaluated the imaging modalities needed to diagnose focal nodular hyperplasia of the liver in children with neuroblastoma who have been followed in our institution for more than 5 years.ResultsOut of 60 children six developed focal nodular hyperplasia at a median time of 10.5 years after diagnosis of neuroblastoma and 9.4 years after the end of treatment. The diagnosis of focal nodular hyperplasia was based on imaging criteria which are variable in ultrasonography and specific in MRI. Only one child underwent surgical biopsies to rule out liver metastases.ConclusionsLongterm survivors of neuroblastoma are at risk of developing focal nodular hyperplasia, especially if they underwent toxic chemotherapy and/or radiotherapy to the liver during initial treatment. The recommended diagnostic imaging tools are ultrasonography for detecting liver lesions and MRI for confirming and characterizing these lesions as focal nodular hyperplasia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Radiology - Volume 74, Issue 3, June 2010, Pages e1–e5
نویسندگان
, , , , , ,