Breast arterial calcifications are correlated with subsequent development of coronary artery calcifications, but their aetiology is predominantly different

ObjectiveTo study whether calcifications in breast arteries, as seen on mammograms, predict future development of coronary artery calcifications.MethodsWe studied 499 women, aged 49–70 years, participating in a breast cancer screening program and investigated whether arterial calcifications in the breast (BAC) are associated with coronary arterial calcifications (CAC) after 9 years follow-up. Mammograms were reviewed for the presence of BAC. CAC was assessed by multi slice computed tomography (MSCT). With logistic regression analysis the independent effect of various risk factors on BAC and CAC was measured.ResultsBAC was present in 58 of 499 women (12%) and CAC score > 0 was present in 262 of 499 women (53%). BAC was strongly associated with CAC (OR 3.2, 95% CI 1.71–6.04) and this remained significant after adjustment for age at baseline and the duration of follow-up (OR 2.1, 95% CI 1.10–4.23). Most CV risk factors were associated with CAC but not with BAC. Only parity was significantly associated with both increased CAC (OR 2.1, 95% CI 1.21–3.60) and increased BAC (OR 5.3, 95% CI 1.23–22.43). Breastfeeding was associated with BAC (OR 3.4, 95% CI 1.40–8.23) but not with CAC (OR 1.3, 95% CI 0.84–1.93).ConclusionBreast arterial calcifications are predictive of subsequent development of calcifications in the coronary arteries.