Imaging of multisystem Langerhans cell histiocytosis in an adult

Langerhans cell histiocytosis (LCH) is a rare disease of uncertain aetiology and is well recognised in children. LCH is characterized by granulomatous infiltration of the lung, bone, skin, lymph nodes, liver, spleen, brain, kidneys, and endocrine system. Manifestations vary depending on whether there is single or multisystem involvement. Clinical symptoms are often non-specific and imaging often plays a vital role in suggesting the diagnosis.We will illustrate and describe the imaging findings of multisystem LCH in an adult patient affecting the lung, liver, thyroid, lymph nodes, suprasellar region, and possibly pancreas. Increased familiarity with the imaging features of multisystem LCH should lead to increased diagnostic confidence and potentially earlier disease diagnosis.