Serial brain MRI in TIA patients

SummaryObjectiveUp to 40% of patients with transient ischemic attack (TIA) demonstrate lesions on diffusion-weighted magnetic resonance imaging (DWI). However, the time course of these ischemic lesions is not well known. Some lesions could vanish soon after symptom onset whereas others could be visible only after a certain delay. Based on a population of TIA patients imaged twice with DWI within the first week after onset, our aim was to estimate the rate of patients with DWI reversible ischemic lesion or with delayed DWI positivity.MethodsWe retrospectively compared DWI at admission (DWI1, median = 15 hours after TIA) with follow-up DWI (DWI2, median = 47 hours) in 64 consecutive TIA over a 7-month period. DWI was reviewed in consensus by two readers, blinded to clinical information. Number, extent and arterial distribution of lesions were assessed.ResultsDWI1 and DWI2 showed similar findings in 55 TIA patients (32 with and 23 without ischemic lesions). In nine (14%) patients, changes were observed on DWI2: presence of ischemic lesions despite normal DWI1 (n = 3), increase in lesion size (n = 3), or partial or complete lesion reversibility (n = 3).ConclusionIn most TIA cases, ischemic lesions captured by early DWI and 48-hour DWI are similar. However, some ischemic lesions vanish rapidly while lesion visibility is delayed in other cases.