کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4319409 | 1290813 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gender- and age-dependent changes in nucleoside levels in the cerebral cortex and white matter of the human brain
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کلمات کلیدی
A1 adenosine receptorsInosineHGPRTADOiNOHYPURD5′-Nucleotidase - 5'-NucleotidaseAdenosine - آدنوزینadenosine deaminase - آدنوزین دآمینازUridine - ادرینUracil - اوراسیل، یوراسیلGender - جنسیتXanthine - زانتیURA - ساعتAge - سنHuman brain - مغز انسانNucleosides - نوکلئوزیدhypoxanthine - هیپوکسانتینhypoxanthine-guanine phosphoribosyltransferase - هیپوکسانتین-گوانین فسفریبوسیل ترانسفرازADA - وجود داردGuo - گواguanosine - گوانوزینGuanine - گوانینA1 receptors - گیرنده های A1A2A receptors - گیرنده های A2AA2A adenosine receptors - گیرنده های آدنوزین A2A
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nucleosides are neuromodulators that participate in various neuronal functions in the brain. In previous studies, we described regional differences in the concentrations of nucleosides and their derivatives in the human brain. To better understand the functions of nucleosides in the central nervous system, we investigated gender- and age-dependent changes in the levels of nucleosides and their metabolites. The concentrations of uridine, inosine, guanosine and adenosine as well as uracil, hypoxanthine and xanthine were measured in the frontal cortex and white matter of post-mortem brain tissue samples of middle-aged and old men as well as women. The average in vivo concentrations calculated from the 40 samples investigated (regardless of anatomical locations, gender or age; mean ± S.E.M.) were as follows (pmol/mg wet tissue weight): 9.7 ± 0.8 adenosine, 85.8 ± 3.9 inosine, 14.3 ± 0.9 guanosine, 37.3 ± 1.8 uridine, 8.9 ± 0.6 uracil, 63.3 ± 2.1 hypoxanthine and 38.7 ± 1.5 xanthine. We conclude that concentration differences between uridine, inosine, guanosine and adenosine in the frontal cortex and cerebral white matter suggest that nucleoside metabolism is altered with aging and regulated differently between men and women.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 81, Issue 6, 5 April 2010, Pages 579-584
Journal: Brain Research Bulletin - Volume 81, Issue 6, 5 April 2010, Pages 579-584
نویسندگان
Zsolt Kovács, Gábor Juhász, Árpád Dobolyi, Mátyás Bobest, Vilmos Papp, Lajos Takáts, Katalin A. Kékesi,