Age of stress exposure modulates the immediate and sustained effects of repeated stress on corticolimbic cannabinoid CB1 receptor binding in male rats

► Stress during adolescence causes a sustained decrease in CB1 receptors in the PFC of adults. ► Following recovery from stress there is an increase in CB1 receptors in the hippocampus. ► CB1 receptor levels in the amygdala increase with advancing age. ► Adolescent rats do not exhibit habituation to stress-induced corticosterone secretion.