Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol

▶2-Arachidonoylglycerol (2-AG) in limbic regions is not altered by swim stress. ▶Limbic 2-AG and serum corticosterone are correlated after a second swim exposure. ▶2-Oleoylglycerol (2-OG) is present in brain and is regionally heterogenous. ▶Prefrontal cortical 2-OG is significantly reduced 24 h after a single swim stress.