A maternal diet supplemented with creatine from mid-pregnancy protects the newborn spiny mouse brain from birth hypoxia

▶We model birth hypoxia using the precocial spiny mouse. ▶Hypoxia significantly increased lipid peroxidation in the cerebrum. ▶Hypoxia caused region-dependent increases in BAX, cytochrome c and caspase-3. ▶Maternal creatine supplementation prevented adverse changes in hypoxia brains. ▶Creatine has neuroprotective capacity for newborn.