کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4359764 1301102 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alveolar macrophages and type I IFN in airway homeostasis and immunity
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Alveolar macrophages and type I IFN in airway homeostasis and immunity
چکیده انگلیسی


• The airways are constantly patrolled by alveolar macrophages.
• Alveolar macrophages are indispensable for tissue homeostasis and host defense.
• Alveolar macrophages are the major source of type I IFN following immune challenge.
• Type I IFNs regulate antimicrobial and inflammatory responses of pulmonary macrophages.
• Eicosanoids modulate type I IFN signaling and production following pathogen invasion.

Globally, respiratory infections cause more than 4 million deaths per year, with influenza and tuberculosis (TB) in particular being major causes of mortality and morbidity. Although immune cell activation is critical for killing respiratory pathogens, this response must be tightly regulated to effectively control and eliminate invading microorganisms while minimizing immunopathology and maintaining pulmonary function. The distinct microenvironment of the lung is constantly patrolled by alveolar macrophages (Mφ), which are essential for tissue homeostasis, early pathogen recognition, initiation of the local immune response, and resolution of inflammation. Here, we focus on recent advances that have provided insight into the relation between pulmonary Mφ, type I interferon (IFN) signaling, and the delicate balance between protective and pathological immune responses in the lung.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 36, Issue 5, May 2015, Pages 307–314
نویسندگان
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