کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4360015 | 1301133 | 2013 | 10 صفحه PDF | دانلود رایگان |
Deregulation of microRNAs (miRNAs) can drive oncogenesis, tumor progression, and metastasis by acting cell-autonomously in cancer cells. However, solid tumors are also infiltrated by large amounts of non-neoplastic stromal cells, including macrophages, which express several active miRNAs. Tumor-associated macrophages (TAMs) enhance angiogenic, immunosuppressive, invasive, and metastatic programming of neoplastic tissue and reduce host survival. Here, we review the role of miRNAs (including miR-155, miR-146, and miR-511) in the control of macrophage production and activation, and examine whether reprogramming miRNA activity in TAMs and/or their precursors might be effective for controlling tumor progression.
► MicroRNAs (miRNAs) modulate macrophage activation.
► miRNAs modulate all stages of macrophage production and amplification.
► miRNAs control macrophage function in tumors.
► Altered miRNA expression in macrophages modulates tumor progression.
Journal: - Volume 34, Issue 7, July 2013, Pages 350–359