کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4361855 1301427 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Poxviral B1 Kinase Overcomes Barrier to Autointegration Factor, a Host Defense against Virus Replication
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Poxviral B1 Kinase Overcomes Barrier to Autointegration Factor, a Host Defense against Virus Replication
چکیده انگلیسی

SummaryBarrier to autointegration factor (BAF) is a DNA-binding protein found in the nucleus and cytoplasm of eukaryotic cells that functions to establish nuclear architecture during mitosis. Herein, we demonstrate a cytoplasmic role for BAF in host defense during poxviral infections. Vaccinia is the prototypic poxvirus, a family of DNA viruses that replicate exclusively in the cytoplasm of infected cells. Mutations in the vaccinia B1 kinase (B1) compromise viral DNA replication, but the mechanism by which B1 achieves this has remained elusive. We now show that BAF acts as a potent inhibitor of poxvirus replication unless its DNA-binding activity is blocked by B1-mediated phosphorylation. These data position BAF as the effector of an innate immune response that prevents replication of exogenous viral DNA in the cytoplasm. To enable the virus to evade this defense, the poxviral B1 has evolved to usurp a signaling pathway employed by the host cell.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 1, Issue 3, 17 May 2007, Pages 187–197
نویسندگان
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