کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4372279 1617059 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High specific immune response to a bivalent anti-HPV vaccine in HIV-1-infected men in São Paulo, Brazil
ترجمه فارسی عنوان
واکنش بالای ایمنی خاص به یک واکسن ضد HPV دو ظرفیتی در مردان آلوده به HIV-1 در سائو پائولو، برزیل
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی

IntroductionInfection with Human papillomavirus (HPV) has been reported as one of the most prevalent agent sexually transmitted diseases, but its true prevalence in men is not precisely known, mainly due to the near absence of symptoms. Moreover, few studies evaluating the post-vaccination immune response have been performed to date in men, hence the hypotheses tested in this study can be important to enable a better understanding of both the immunopathogenesis and the response to vaccination in HIV-infected patients, and to help in the elaboration of strategies of vaccination against HPV in the HIV-infected population.ObjectivesTo analyze the specific response to antigens of HPV vaccine in HIV-infected men.MethodsA total of 25 HIV-infected male patients who met the inclusion criteria during the data collection period were vaccinated; however, six (30%) had anti-HPV at baseline, and were not considered further in the analysis. Therefore, 19 HIV-infected individuals were included in the study, along with five healthy, HPV-seronegative controls.ResultsPatients infected with HIV-1 were subdivided into two groups, A and B, according to their T CD4 cells count at the time of vaccination, namely: Group A: CD4>500; Group B: CD4<500. The proportion of seroconversion after immunization with three doses of a bivalent anti-HPV vaccine was 92%.ConclusionHIV-infected patients as well as HIV negative controls responded to anti-HPV vaccination, regardless of their T CD4 cells count and HIV plasma viral load. These results demonstrate that anti-HPV immunization in HIV-infected males is effective and should be encouraged, thus helping to decrease the risk of infection, mortality and morbidity of diseases associated with HPV in men.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Papillomavirus Research - Volume 2, December 2016, Pages 17–20
نویسندگان
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