کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4408649 | 1618852 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Particle-water interactions of platinum-based anticancer drugs in river water and estuarine water
ترجمه فارسی عنوان
تعامل ذرات آب از مواد ضد سرطان مبتنی بر پلاتین در آب های رودخانه و آب های استوایی
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کلمات کلیدی
داروهای سیتوتوکسیک، پلاتین، جذب، رودخانه، رودخانه، رسوب،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
The cytotoxic, platinum-based anticancer drugs, cisplatin, carboplatin and oxaliplatin, enter the aquatic environment largely in municipal wastes via excretion from outpatients undergoing chemotherapy. The environmental behaviour, effects and fate of these drugs are, however, unknown. In this study, the adsorption of the drugs to untreated and chemically modified (oxide-free and organic-free) sediment was examined in both river water and low salinity (S = 3.2) estuarine water in order to determine the nature and extent of their interactions with suspended particles. In all cases, adsorption isotherms were linear, and the slopes of the relationships, or distribution coefficients (KDs), ranged from about 102 to 103 ml gâ1. Overall, adsorption decreased in the order: cisplatin > carboplatin > oxaliplatin; in river water and: cisplatin > carboplatin, oxaliplatin; in estuarine water. There was no clear dependence of adsorption on sediment treatment but, for all sediment types, both cisplatin and carboplatin adsorption was greater in river water than in estuarine water. Qualitatively, these observations are consistent with the rates of formation of reactive, aquated degradation products and the dependencies of these rates on aqueous chloride concentration. We predict that during transport through an estuarine turbidity maximum (of suspended sediment concentration = 1 g Lâ1), up to about 45% of cisplatin and 35% of carboplatin are filtered out from the aqueous phase but that no more than 7% of oxaliplatin is retained.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 119, January 2015, Pages 415-422
Journal: Chemosphere - Volume 119, January 2015, Pages 415-422
نویسندگان
Andrew Turner, Llucia Mascorda,