کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4500500 1319998 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bifurcation analysis of a model for hormonal regulation of the menstrual cycle
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Bifurcation analysis of a model for hormonal regulation of the menstrual cycle
چکیده انگلیسی

A model for hormonal control of the menstrual cycle with 13 ordinary differential equations and 41 parameters is presented. Important changes in model behavior result from variations in two of the most sensitive parameters. One parameter represents the level of estradiol sufficient for significant synthesis of luteinizing hormone, which causes ovulation. By studying bifurcation diagrams in this parameter, an interval of parameter values is observed for which a unique stable periodic solution exists and it represent an ovulatory cycle. The other parameter measures mass transfer between the first two stages of ovarian development and is indicative of healthy follicular growth. Changes in this parameter affect the uniqueness interval defined with respect to the first parameter. Hopf, saddle-node and transcritical bifurcations are examined. To attain a normal ovulatory menstrual cycle in this model, a balance must be maintained between healthy development of the follicles and flexibility in estradiol levels needed to produce the surge in luteinizing hormone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 225, Issue 2, June 2010, Pages 108–114
نویسندگان
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