کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4502577 1320580 2011 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamic modeling of cooperative protein secretion in microorganism populations
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Dynamic modeling of cooperative protein secretion in microorganism populations
چکیده انگلیسی

Interactions between microorganisms can have a crucial effect on their population dynamics. Typically, interactions are mediated through the environment by molecules and proteins that are products of cell metabolism and physiology; they therefore reflect the internal dynamics of the single cell. In this work we aim to integrate single-cell properties of gene expression that affect indirect interactions between microorganisms under challenging conditions, into a quantitative model of population dynamics. Specifically we address the problem of a microbial population secreting a protein that can actively extract a growth-limiting resource, such as a simple sugar or iron, from the environment. The genes coding for the protein can undergo random epigenetic transitions between active and silenced states, and can be repressed by the product of their reaction. We model cooperative and competitive interactions between protein producing and non-producing phenotypes by nonlinear dynamical systems and analyze them both in terms of asymptotic states and of transient dynamics. Our model shows that phenotypic transitions allow a stable coexistence of the two phenotypes, and enables us to make predictions regarding the conditions required for such coexistence and the typical timescales of transient dynamics. It also shows how repression by the reaction product induces a feedback at the population-environment level that can result in limit cycle dynamics. The relation of these results to experiments are discussed.


► Microbes secrete proteins that extract an essential resource from the environment.
► Varied protein production phenotypes are modeled by nonlinear dynamical systems.
► Instability of phenotypes can allow a stable mix of producers and non-producers.
► Total Population Density and Internal Composition typical timescales emerge.
► Repression of protein production by the resource can result in limit cycle dynamics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Theoretical Population Biology - Volume 80, Issue 1, August 2011, Pages 49–63
نویسندگان
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