Nose to brain delivery in rats: Effect of surface charge of rhodamine B labeled nanocarriers on brain subregion localization

Schematic representation of rhodamine-labeled NPs distribution, 8, 24 and 48 h after IN administration in rat. Red spot indicates NPA; blue-red spot indicates NPBC3. The intense, moderate and weak labeling correspond to large, medium and small spots respectively. The brain areas investigated are: cerebral cortex (beige); basal ganglia (light blue); hippocampus (green); thalamus (pink); mesencephalon (orange); cerebellar cortex and nuclei (violet); myelencephalon (yellow).