کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5135754 | 1493450 | 2016 | 5 صفحه PDF | دانلود رایگان |
- The chiral separation of hexahelicenes is reported.
- Helicene and its imidazolium derivative are included in the study.
- 1-Butyl-3-(2-methyl[6]helicenyl)-imidazolium was prepared in enantiopure forms.
- CE, HPLC and SFC were utilized for the resolution of P and M enantiomers.
In this short communication we report optimized procedures for the chiral separation of non-charged [6]helicene (1) and cationic derivative 1-butyl-3-(2-methyl[6]helicenyl)-imidazolium bromide (2) using high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC) methods. The possibility of using capillary electrophoresis (CE) was also tested. The satisfactory results were obtained with SFC, where the highly selective resolution of four enantiopure 1 and 2 helicenes was achieved in a single run within 5Â min. The semi-preparative procedure for the isolation of P and M enantiomers of compound 2, including circular dichroism data, is reported here for the first time. The results could be used in further separations and analytical applications targeting carbohelicenes vs. positively charged helicene derivatives.
Journal: Journal of Chromatography A - Volume 1476, 9 December 2016, Pages 130-134