کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137563 | 1494530 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential peripheral blood methylation by α-lipoic acid and EPA supplementation in overweight or obese women during a weight loss program
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کلمات کلیدی
FFARegulatory associated protein of mTORCREBBPTRRAPPUFAsFDRPBMCEPAα-Lipoic acid - اسید α-لیپوئیکEicosapentaenoic acid - اسید ایکوزاپنتانوئیکdocosahexaenoic acid - اسید داکوزاگزوائونیکPolyunsaturated fatty acids - اسید چرب اشباع نشدهFree fatty acids - اسیدهای چرب آِزادOmega-3 - امگا 3Epigenetics - اپی ژنتیکanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceDHA - دوکوساهگزائنوئیک اسیدperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیLipoic acid - لیپوئیک اسیدMethylation - متیلاسیونfalse discovery rate - میزان کشف کاذبCREB binding protein - پروتئین اتصال CREBWeight loss - کاهش وزنHAT - کلاه
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential peripheral blood methylation by α-lipoic acid and EPA supplementation in overweight or obese women during a weight loss program Differential peripheral blood methylation by α-lipoic acid and EPA supplementation in overweight or obese women during a weight loss program](/preview/png/5137563.png)
چکیده انگلیسی
This study aims to assess methylation modifications in blood cell genes induced by eicosapentaenoic acid (EPA) and/or α-lipoic acid (LA) supplementation, and their potential relationship with metabolic risk biomarkers. Healthy overweight/obese women were assigned to 4 experimental groups (control or groups supplemented with 1.3 g EPA/day, 0.3 g LA/day, or both), all followed a 10-week hypocaloric diet. White blood cells DNA was hybridized in Human-450K-methylation microarray. Differentially methylated CpGs (post-pre) were identified in supplemented groups, including CpG regions from NCK2, FITM2, TRRAP, RPTOR and CREBBP genes. In peripheral blood mononuclear cells (PBMC), LA upregulated NCK2, TRRAP and RPTOR mRNA, which negatively associated with changes in body weight and fat mass. Changes in cg10320884 (TRRAP) methylation site negatively correlated with changes in TRRAP mRNA in PBMC, and positively with Framingham score. Further studies are needed to better characterize the potential involvement of epigenetics in the actions of LA and EPA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 36, September 2017, Pages 178-185
Journal: Journal of Functional Foods - Volume 36, September 2017, Pages 178-185
نویسندگان
Ana E. Huerta, José I. Riezu-Boj, FermÃn I. Milagro, Elisabet Guruceaga, MarÃa J. Moreno-Aliaga, J. Alfredo MartÃnez,