کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5138197 1494597 2017 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Simple on-line pretreatment of column-switching coupled with ion chromatography for the determination of lactic acid in lobaplatin
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Simple on-line pretreatment of column-switching coupled with ion chromatography for the determination of lactic acid in lobaplatin
چکیده انگلیسی
In this study, a simple and sensitive on-line pretreatment of column-switching technique coupled with ion chromatography method was achieved for the determination of key impurity of lactic acid in lobaplatin. The first dimension of reverse phase liquid chromatography was used to reduce organic matrices, whereas the second dimension of ion chromatography was applied for the separation and detection of lactic acid. The results exhibited good linearity (R = 0.9994) ranging from 0.01 mg L−1 to 50 mg L−1. The limit of detection was below 0.0015 mg L−1. Also, a spiking study was performed with satisfactory recoveries between 96% and 106%.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 138, 10 May 2017, Pages 316-321
نویسندگان
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