Recent advances in simultaneous electrochemical multi-analyte sensing platforms

Biosensors combine the sensitivity of detection technology with the specificity of a designated biological entity. Owing to their specificity and sensitivity, biosensors are applied for sensing and monitoring of different diseases. Simultaneous sensing of myriad of biomarkers in different diseases at the early stages is swiftly finding its way towards disease's hallmarks, even though the biological contexts are complex matrices with possible cross-reactivity of restrained biomolecules. Electrochemical biosensors are considered as simple and cost-effective methods, which make the concurrent detection of multiple biomarkers plausible for ultimate diagnosis of diseases in clinic. Simultaneous sensing of multiple biomarkers by electrochemical techniques can be achieved through either multi-label or multi-electrode approaches, which can be implemented as miniaturized screen-printed or even lab-on-a-chip systems. Here, we reviewed literature (2000-2016) and provided a comprehensive insight on various biosensing platforms, articulating the most recent advancements in each type of biosensors applied for the detection of biomolecules.