کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5142610 | 1496269 | 2017 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dietary phytochemicals in the protection against oxysterol-induced damage
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کلمات کلیدی
VCAM-15β,6β-epoxycholesterolcholestan-3β,5α,6β-triolMDA7KCSOPsNOX1ICAM-1CoPSGSHGPX24-Hydroxycholesterol - 24 هیدروکسی کلسترول5α,6α-epoxycholesterol - 5α، 6α-اپوکسیکلسترول7-Ketocholesterol - 7-کتو کلسترول7β-hydroxycholesterol - 7β-هیدروکسی کلسترولROS - ROSPOPs - آلایندههای آلی دیرپاVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)malonyldialdehyde - مالونی دی آلدئیدsterol oxidation products - محصولات اکسیداسیون استرولPhytosterol oxidation products - محصولات اکسیداسیون فیتوسترولCholesterol oxidation products - محصولات اکسیداسیون کلسترولintercellular adhesion molecule-1 - مولکول چسبندگی بین سلولی -1vascular cell adhesion molecule-1 - مولکول چسبندگی سلولی عروقی-1reduced glutathione - کاهش گلوتاتیونglutathione peroxidase - گلوتاتیون پراکسیدازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The intake of fruits and vegetables is associated with reduced incidence of many chronic diseases. These foods contain phytochemicals that often possess antioxidant and free radical scavenging capacity and show anti-inflammatory action, which are also the basis of other bioactivities and health benefits, such as anticancer, anti-aging, and protective action for cardiovascular diseases, diabetes mellitus, obesity and neurodegenerative disorders. Many factors can be included in the etiopathogenesis of all of these multifactorial diseases that involve oxidative stress, inflammation and/or cell death processes, oxysterols, i.e. cholesterol oxidation products (COPs) as well as phytosterol oxidation products (POPs), among others. These oxidized lipids result from either spontaneous and/or enzymatic oxidation of cholesterol/phytosterols on the steroid nucleus or on the side chain and their critical roles in the pathophysiology of the abovementioned diseases has become increasingly evident. In this context, many studies investigated the potential of dietary phytochemicals (polyphenols, carotenoids and vitamins C and E, among others) to protect against oxysterol toxicity in various cell models mimicking pathophysiological conditions. This review, summarizing the mechanisms involved in the chemopreventive effect of phytochemicals against the injury by oxysterols may constitute a step forward to consider the importance of preventive strategies on a nutritional point of view to decrease the burden of many age-related chronic diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 207, Part B, October 2017, Pages 192-205
Journal: Chemistry and Physics of Lipids - Volume 207, Part B, October 2017, Pages 192-205
نویسندگان
Antonio Cilla, Amparo AlegrÃa, Alessandro Attanzio, Guadalupe Garcia-Llatas, Luisa Tesoriere, Maria A. Livrea,