کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5157130 1500590 2017 31 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alginate microparticles as oral colon drug delivery device: A review
ترجمه فارسی عنوان
میکرواستراتژی آلژینات به عنوان دستگاه تحویل داروی خوراکی کولون: بررسی
کلمات کلیدی
آلژینات، ذرات کوچک، بیماری های التهابی روده تحویل دارو کولون، اتصال دوطرفه،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
The increase in the research interest on alginate microparticles in pharmaceutical and biomedical areas confirms its potential use as an effective matrix for drug and cell delivery. Among the well known alginate properties, pH sensitivity remains as an attractive option for targeting of drug in the colon region. This essential aspect is advantageous to enhance therapeutic efficacy of treatment of inflammatory bowel diseases, which require multi-drug administration frequently in a long period. As consequence, severe side effect appears leading to discontinuation of therapy and affecting quality of patient life. This review gives an overview of relevant properties of alginate as oral colon delivery systems and the recent innovative strategies of using alginate with other polymers as well as microencapsulation techniques. At the same time, it describes the several advantages of coating processes involving alginate over microparticles in order to design better material with sustained release characteristic for colon-targeted delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 168, 15 July 2017, Pages 32-43
نویسندگان
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